Palmitoyl Pentapeptide-4 powder

Palmitoyl Pentapeptide-4 Powder | 98% HPLC Purity | Cosmetic Grade Manufacturer

Shaanxi Zhenhuacui Biotechnology sells pharmaceutical-grade Palmitoyl Pentapeptide-4 powder (CAS: 214047-00-4). It is ≥98% pure via HPLC. Our cosmetic-grade material is created using SPPS. It has a molecular weight of 802.05 Da, ≥80% peptide content, and can tolerate temperatures up to 60°C. ISO9001/cGMP/HALAL certifications, over 10 years of peptide synthesis experience, a 60% R&D team ratio for bespoke requirements, a 100g MOQ, and rapid shipment for stock goods within 7–10 days are some of the company's advantages.

Product Specifications

Mechanism of Action

Biomimetic Matrikine Signaling

Palmitoyl pentapeptide-4, a synthetic matrikine mediator, resembles collagen breakdown products. Skin fibroblasts produce extracellular matrix faster when the pentapeptide sequence Lys-Thr-Thr-Lys-Ser is present.

Lipophilic Enhancement

The addition of the palmitoyl (C16) fatty acid changes the water-loving peptide into a fat-loving molecule, which lets:

• Better entry into the layer corneum
• Bioavailability is better than with non-conjugated peptides.
• Integration into emulsion systems that is stable

Collagen Synthesis Pathway

Starts the TGF-β signalling chain, which helps with

• Collagen Type I: The main structural protein (67% more studies in vitro)
• Type III collagen: fibres that support networks
• Type IV collagen: keeping the basement barrier strong
• GFAGs and fibronectin: Full return of ECM

Performance Benefits

Anti-Aging Efficacy

• Wrinkle Reduction: After 12 weeks, clinical tests show a 17–21% change in the depth of the nasolabial folds.
• Skin Firmness: An 8–10% rise in skin density as measured by ultrasound
• Improved durability through elastin fibre network support for elasticity recovery

Formulation Advantages

• Very Low Dosage: It works in finished goods at 3 to 8 ppm (0.0003% to 0.0008%).
• A kilogram of raw material can make between 125,000 and 330,000 units (30 ml of serum at 5ppm).
• Stability at high temperatures: can handle normal emulsification processes up to 60°C. Stability at normal facial pH levels (4.0–7.0).
• Alternative to retinoids that doesn't irritate the skin and is in line with INCI standards

Broad Compatibility

Works with popular chemicals in cosmetics:

• Creams with hyaluronic acid
• Formulations of niacinamide
• Different forms of vitamin C
• Beta-hydroxy acids (pH checked)
• Extracts from plants

Application Categories

Manufacturing Process

SPPS Technology (Solid Phase Peptide Synthesis)

Stage 1: Chain Assembly

Automated sequential coupling of Fmoc-protected amino acids on Wang resin is carried out using Palmitoyl Pentapeptide-4 powder. Each cycle includes:

• Deprotection with 20% piperidine/DMF
• Coupling with HBTU/HOBt activation
• Capping of unreacted sequences

Stage 2: Palmitoylation

N-terminal acylation with palmitic acid using DIC/HOBt chemistry under nitrogen atmosphere.

Stage 3: Cleavage & Precipitation

TFA cocktail cleavage (TFA/TIS/H₂O 95:2.5:2.5) followed by cold ether precipitation.

Stage 4: Purification

• Preparative RP-HPLC (C18 column, water-acetonitrile gradient)
• Multiple passes to achieve ≥98% purity
• Desalting via gel filtration

Stage 5: Lyophilization

Freeze-drying at -50°C under 0.1 mbar vacuum for 48-72 hours.

Stage 6: Quality Control

• HPLC purity analysis (≥98%)
• Mass spectrometry confirmation
• Peptide content assay (≥80%)
• Karl Fischer water content (≤5%)
• Microbial testing (USP standards)

Quality Certifications

Our GMP-compliant facility maintains:

• ISO 9001:2015 – Quality Management System
• cGMP – Current Good Manufacturing Practice (Cosmetic Grade)
• FSSC 22000 – Food Safety System Certification
• HACCP – Hazard Analysis Critical Control Points
• HALAL – Islamic Compliance (JAKIM certified)
• KOSHER – Orthodox Union supervision
• Organic Certification – USDA/EU equivalent standards

All batches include:

• Certificate of Analysis (COA)
• HPLC chromatogram
• Mass spectrum report
• Microbial test results
• Heavy metal analysis
• Material Safety Data Sheet (MSDS)

Packaging & Logistics

Standard Packaging

Custom Packaging

OEM/ODM clients may specify:

• Branded labeling
• Vacuum-sealed portions

Global Shipping

• Express (5-7 days): DHL, FedEx, UPS for ≤100kg
• Air Freight (5-10 days): For 100-500kg urgent orders
• Sea Freight (25-35 days): Cost-effective for >500kg

Standard Lead Time: 7-10 days (stock items) | 20 working days (custom orders)

Technical Support Services

Pre-Sales Consultation

• Formulation compatibility assessment
• Dosage optimization recommendations
• Stability data provision

R&D Collaboration

With 60% staff dedicated to research, we offer:

• Custom purity grades (up to 99%+)
• Analytical method development
• Formulation stability testing (3/6/12-month accelerated studies)

Regulatory Support

• Global cosmetic registration dossiers
• Allergen-free declarations
• Vegan/Cruelty-free certifications

Our Warehouse

Our Teams & Exhibitions

FAQ

Q: How is palmitoylation more effective than Palmitoyl Pentapeptide-3?

A: Both target collagen production, but Matrixyl has 20+ years of clinical validation and better documentation. A particular Lys-Thr-Thr-Lys-Ser sequence optimises receptor binding.

Q: Can this replace retinol in anti-aging products?

A: Clinical trials indicate comparable wrinkle reduction without retinol's photosensitivity, irritation, and pregnancy contraindications. Excellent for delicate skin and daily products.

Q: What degrades formulation peptides?

A: Key elements:

• Hydrolysis occurs at pH <4.0 or >7.0.
• Extended temperatures >60°C
• Peroxides (without protection)

Q: Are these plant extracts with proteolytic enzymes vegan and cruelty-free?

A: Yes. Made from plant-derived amino acids utilising SPPS. Animal-free materials and testing. Certifications upon request.

Q: How should opened samples be stored?

A: Reseal with desiccant immediately. Darkly store at 2-8°C. Within 6 months after opening. Store over a year at -20°C with argon flushing.

Q: Do you advise formulation?

A: Yes. Tech data sheet included with sample orders.

• Tips for solubilisation
• pH-adjusting treatments
• Missing compatibility
• Preservation methods suggested

Why Shaanxi Zhenhuacui Biotechnology

Manufacturing Excellence

• 10+ Years specialized in peptide synthesis and plant extract biotechnology
• GMP-Certified production facility with Class 100,000 cleanroom
• Advanced SPPS automated synthesizers ensuring batch consistency
• Vertical Integration from raw amino acids to finished powder

Research Capabilities

• 60% R&D Workforce 
• Formulation Lab for stability and compatibility testing

Flexible Business Terms

• Low MOQ: 100g minimum (sample testing supported)
• Scalable Production: From grams to metric tons
• OEM/ODM: White-label finished products (serums, creams, masks)
• Payment Terms: T/T, L/C, PayPal (for samples)

Global Service Network

• Multilingual Support: English, Spanish, Russian, Arabic
• Time Zone Coverage: Response within 12 hours
• Regulatory Expertise: FDA, EU, NMPA
• After-Sales Service: Technical troubleshooting and reformulation support

Contact Us

Do you have more questions about Palmitoyl Pentapeptide-4 powder? Email: plantex@asianbios.com