Syn-Ake powder

Syn-Ake Powder (98% HPLC) | Solid Phase Synthesis | cGMP Certified Manufacturer

Through modern Solid Phase Peptide Synthesis, our Syn-Ake powder is 98% pure (HPLC confirmed), which meets pharmaceutical-grade standards for anti-wrinkle cosmetics. As a manufacturer that is approved by cGMP, FSSC22000, and ISO9001, we can keep making things and send them in 10 days for orders starting at 100g MOQ. Our center has over 10 years of experience with peptide synthesis and a staff that is 60% focused on research and development. This makes sure that batch-to-batch consistency for B2B clients who need scalable supply chains.

What is Syn-Ake Powder?

Dipeptide Diaminobutyroyl Benzylamide Diacetate, or Syn-Ake powder, is a man-made hexapeptide that is meant to look like Waglerin-1, a peptide that is found in temple viper venom. In order to soften expression lines, it blocks reversibly acetylcholine receptors, which slows down the transfer of neuromuscular signals.

How it works:

During the post-synaptic membrane, it stops muscles from contracting. This stops repeated face movements and makes dynamic wrinkles like crow's feet, forehead lines, and glabellar furrows look smoother.

List of Chemicals:

• Powder that is clear and white
• so that it can be easily mixed into formulations
• pH 5.0 to 7.0 systems are stable.
• Gels, emulsions, and dry bases can all be used with it.

Technical Specifications

Quality Certifications & Compliance

We have the following globally recognised certifications to make sure that our products are safe and that we follow all global regulations:

Standards for manufacturing:

• Current Good Manufacturing Practice, or cGMP
• Management of Quality ISO9001:2015

Safety and Traceability in the FSSC22000 Food Safety System:

• How to Do a HACCP Hazard Analysis
• Certificate of Analysis (COA) for each batch

Full set of paperwork (MSDS, allergy statement, and BSE/TSE free declaration) Certifications for specific markets:

• HALAL (for markets in the Middle East)
• KOSHER (for sales in North America)
• Organic Certification is available if you ask for it.

A third party checks all of the goods for heavy metals (Pb, As, Hg, and Cd), microbiological pollution.

Production Process: Six-Stage Quality Control

Stage 1: Amino Acid Coupling

During solid-phase synthesis, protective amino acids are added one at a time to resin supports, which forms the peptide chain. Our automatic synthesisers make sure that the connection rate is at least 99.5% per cycle.

Stage 2: Cleavage & Deprotection

Trifluoroacetic acid (TFA) is used to cut the finished peptide from the glue. The side chains are then deprotected under controlled conditions to stop oxidation.

Stage 3: Crude Purification

Preparative HPLC gets rid of reaction by-products, shortened sequences, and delete peptides. With this step, purity goes from about 70% to 95% or more.

Stage 4: Final Purification

It is ≥98% pure after a second HPLC run with gradients that have been optimised. Mass spectrometry (MS) is used for in-process testing to determine molecular weight.

Stage 5: Lyophilization

Freeze-drying turns the clean fluid into a stable powder. For longer shelf life, we keep the remaining wetness below 3%.

Stage 6: QC Release

The final batch test includes:

• HPLC measurement of purity (USP method)
• Test for peptide amount
• Test for microbe limits (USP <61>/<62>)
• Tests for heavy metals (ICP-MS)

Cosmetic Applications & Formulation Guidelines

Recommended Use Levels

Formulation Compatibility

Ingredients that work together:

• Acetyl Hexapeptide-8 (helped muscles soften)
• Hyaluronic Acid (keeps skin moist and full)
• Niacinamide (helps with barriers)
• Matrixyl 3000 (making collagen)

Avoid putting together with:

• Acids that are very strong (pH <4.0)
• Very high temps (above 50°C) during processing
• Direct UV radiation while the product is being made

Stability Data

Tests of accelerated stability (40°C/75% RH, 3 months) show:

• Purity kept: at least 95%
• The finished goods don't change colour.

Keeps working in emulsions with pH 5.5 to 6.5

Why Partner With Shaanxi Zhenhuacui Biotechnology?

1. Scalable Production Capacity

In a month, our 5,000-square-meter GMP plant handles more than 2,000 kg of peptides. We keep a steady supply, whether you need 100g for trial runs or 500kg for mass production.

2. R&D Collaboration

This is what our R&D team (60 percent of the staff) is good at:

• Custom production of peptides
• Optimising the formulation
• Improvements to stability

3. Fast Turnaround & Logistics

• Items in stock: DHL or FedEx within 10 days to ship
• Custom orders take 20 days to make.
• Express service: finishing in 7 days instead of 14 (extra fee applies)

We keep appropriate amounts of inventory to keep supplies from running out.

4. Flexible Business Terms

• Low MOQ of 1000g for companies and R&D teams
• Free samples (you have to pay for shipping)
• OEM/ODM services with your own brand

You can pay with T/T, L/C, or PayPal (for trial sales).

5. Regulatory Support

We offer full paperwork packages for

• Cosmetics Regulation (EC) No 1223/2009 in the EU
• US FDA beauty registration China NMPA filing (cosmetics brought in from other countries)
• Following the ASEAN Cosmetic Directive

Packaging

Our Teams & Exhibitions

FAQ

Q: What analytical approach verifies 98% purity?

A: We employ USP monograph reverse-phase HPLC with 220nm UV detection. COA chromatograms are included with each batch.

Q: What distinguishes your product from acetyl hexapeptide-8?

A: Both are muscle-relaxing peptides, however Syn-Ake targets post-synaptic nicotinic acetylcholine receptors while Argireline impacts pre-synaptic SNARE complex. With 2%+2% concentration, they synergise.

Q: What should I do with powder during formulation?

A: First dissolve in water at 20-30°C before adding to the main formulation. Avoid overheating above 50°C. For best results, use within 4 hours of dissolution.

Request Documentation & Samples

To receive the following materials, contact our technical team:

Available Documents:

• Certificate of Analysis (COA)
• Material Safety Data Sheet (MSDS)
• Technical Data Sheet (TDS)

Sample Policy:

100g samples available at production cost. Shipping via express courier (3-5 business days globally). Sample fee refundable on first commercial order ≥100kg.

Contact Us

Do you have more questions about Syn-Ake powder? Email: plantex@asianbios.com